Structural brain changes throughout adulthood
نویسندگان
چکیده
Introduction The advent of quantitative techniques based on the analyses of MRI structural data, such as Voxel-Based Morphometry (VBM) and volumetric analyses, has allowed a sensitive detection of regional patterns of grey matter (GM) and white matter (WM) volume loss with ageing (Sowell et al., 2003; Walhovd et al., 2005). More recently, diffusion tensor imaging (DTI) has been used to quantify alterations in WM microstructure in the ageing brain (Salat et al., 2005). However, there is mixed evidence over the correspondence between changes detected using conventional volume or VBM measurements and DTI. The aim of this study was to determine the timing and spatial distribution of age-related changes using a range of volumetric and DTI-based measures.
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